Functional analysis of clinical BARD1 germline variants

Germline pathogenic variants in BRCA1/2 account for one-third of familial breast cancers. The majority of BRCA1 function requires heterodimerization with BARD1. In contrast to BRCA1, BARD1 is a low-penetrance gene with an unclear clinical relevance, partly because of limited functional evidence. Usi...

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Bibliografiske detaljer
Udgivet i:Cold Spring Harb Mol Case Stud
Main Authors: Toh, Ming Ren, Chong, Siao Ting, Chan, Sock Hoai, Low, Chen Ee, Ishak, Nur Diana Binte, Lim, Jing Quan, Courtney, Eliza, Ngeow, Joanne
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672023/
https://ncbi.nlm.nih.gov/pubmed/31371347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a004093
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