Motor Neuron Disease Occurring in a Mutant Dynactin Mouse Model Is Characterized by Defects in Vesicular Trafficking

Amyotrophic lateral sclerosis (ALS), a fatal and progressive neurodegenerative disorder characterized by weakness, muscle atrophy, and spasticity, is the most common adult-onset motor neuron disease. Although the majority of ALS cases are sporadic, ∼5–10% are familial, including those linked to muta...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Laird, Fiona M., Farah, Mohamed H., Ackerley, Steven, Hoke, Ahmet, Maragakis, Nicholas, Rothstein, Jeffrey D., Griffin, John, Price, Donald L., Martin, Lee J., Wong, Philip C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671836/
https://ncbi.nlm.nih.gov/pubmed/18305234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4231-07.2008
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