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Optical Reporters for the Conformation of α-Synuclein Reveal a Specific Interaction with Mitochondria

The aggregation of abnormally folded proteins is a defining feature of neurodegenerative disease, but it has not previously been possible to assess the conformation of these proteins in a physiologically relevant context, before they form morphologically recognizable aggregates. We now describe FRET...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Nakamura, Ken, Nemani, Venu M., Wallender, Erika K., Kaehlcke, Katrin, Ott, Melanie, Edwards, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671709/
https://ncbi.nlm.nih.gov/pubmed/19020024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3088-08.2008
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