Transplanted Mouse Embryonic Stem-Cell-Derived Motoneurons Form Functional Motor Units and Reduce Muscle Atrophy

Prolonged muscle denervation resulting from motor neuron (MN) damage leads to atrophy and degeneration of neuromuscular junctions (NMJs), which can impart irreversible damage. In this study, we ask whether transplanted embryonic stem (ES) cells differentiated into MNs can form functional synapses wi...

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Publicat a:J Neurosci
Autors principals: Yohn, Damien C., Miles, Gareth B., Rafuse, Victor F., Brownstone, Robert M.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671703/
https://ncbi.nlm.nih.gov/pubmed/19020033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1761-08.2008
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