Analgesic α-Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABA(B) Receptor Activation

α-Conotoxins Vc1.1 and Rg1A are peptides from the venom of marine Conus snails that are currently in development as a treatment for neuropathic pain. Here we report that the α9α10 nicotinic acetylcholine receptor-selective conotoxins Vc1.1 and Rg1A potently and selectively inhibit high-voltage-activ...

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Vydáno v:J Neurosci
Hlavní autoři: Callaghan, Brid, Haythornthwaite, Alison, Berecki, Géza, Clark, Richard J., Craik, David J., Adams, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671365/
https://ncbi.nlm.nih.gov/pubmed/18945902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3594-08.2008
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