Knock-In Mice Lacking the PDZ-Ligand Motif of mGluR7a Show Impaired PKC-Dependent Autoinhibition of Glutamate Release, Spatial Working Memory Deficits, and Increased Susceptibility to Pentylenetetrazol

The metabotropic glutamate receptor 7 (mGluR7) is widely expressed throughout the brain and primarily localized at presynaptic active zones, where it is thought to regulate neurotransmitter release. Protein interacting with C kinase 1 (PICK1), a postsynaptic density protein-95/disc-large tumor suppr...

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Pubblicato in:J Neurosci
Autori principali: Zhang, Chuan-Sheng, Bertaso, Federica, Eulenburg, Volker, Lerner-Natoli, Mireille, Herin, Greta Ann, Bauer, Liane, Bockaert, Joel, Fagni, Laurent, Betz, Heinrich, Scheschonka, Astrid
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671056/
https://ncbi.nlm.nih.gov/pubmed/18716219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0628-08.2008
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