P2Y(12) Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain

Microglia in the spinal cord may play an important role in the development and maintenance of neuropathic pain. A metabotropic ATP receptor, P2Y(12), has been shown to be expressed in spinal microglia constitutively and be involved in chemotaxis. Activation of p38 mitogen-activated protein kinase (M...

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Published in:J Neurosci
Main Authors: Kobayashi, Kimiko, Yamanaka, Hiroki, Fukuoka, Tetsuo, Dai, Yi, Obata, Koichi, Noguchi, Koichi
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670682/
https://ncbi.nlm.nih.gov/pubmed/18337420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5589-07.2008
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