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μ-Opioid Receptor-Mediated Depression of the Hypothalamic Hypocretin/Orexin Arousal System
Arousal and maintenance of a wake state is dependent on the hypothalamic hypocretin/orexin system. We found that hypocretin neurons are depressed by opiates, drugs of abuse that reduce cognitive alertness. Met-enkephalin (mENK), an endogenous opioid, and exogenous opiates such as morphine inhibited...
Gespeichert in:
| Veröffentlicht in: | J Neurosci |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Society for Neuroscience
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6670680/ https://ncbi.nlm.nih.gov/pubmed/18337411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5447-07.2008 |
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