μ-Opioid Receptor-Mediated Depression of the Hypothalamic Hypocretin/Orexin Arousal System

Arousal and maintenance of a wake state is dependent on the hypothalamic hypocretin/orexin system. We found that hypocretin neurons are depressed by opiates, drugs of abuse that reduce cognitive alertness. Met-enkephalin (mENK), an endogenous opioid, and exogenous opiates such as morphine inhibited...

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Sparad:
Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Li, Ying, van den Pol, Anthony N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2008
Ämnen:
Brief Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670680/
https://ncbi.nlm.nih.gov/pubmed/18337411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5447-07.2008
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