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Purkinje-Cell-Restricted Restoration of Kv3.3 Function Restores Complex Spikes and Rescues Motor Coordination in Kcnc3 Mutants

The fast-activating/deactivating voltage-gated potassium channel Kv3.3 (Kcnc3) is expressed in various neuronal cell types involved in motor function, including cerebellar Purkinje cells. Spinocerebellar ataxia type 13 (SCA13) patients carrying dominant-negative mutations in Kcnc3 and Kcnc3-null mut...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Hurlock, Edward C., McMahon, Anne, Joho, Rolf H.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670432/
https://ncbi.nlm.nih.gov/pubmed/18448641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5486-07.2008
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