Effects of Comedication and Genetic Factors on the Population Pharmacokinetics of Lamotrigine: A Prospective Analysis in Chinese Patients With Epilepsy

Lamotrigine (LTG) is a second-generation anti-epileptic drug widely used for focal and generalized seizures in adults and children, and as a first-line medication in pregnant women and women of childbearing age. However, LTG pharmacokinetics shows high inter-individual variability, thus potentially...

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Publicado en:Front Pharmacol
Autores principales: Wang, Zhan-zhang, Zhang, Yue-feng, Huang, Wen-can, Wang, Xi-pei, Ni, Xiao-jiao, Lu, Hao-yang, Hu, Jin-qing, Deng, Shu-hua, Zhu, Xiu-qing, Xie, Huan-shan, Chen, Hong-zhen, Zhang, Ming, Qiu, Chang, Wen, Yu-guan, Shang, De-wei
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669232/
https://ncbi.nlm.nih.gov/pubmed/31404235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00832
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