Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated

In this study we interrogated the DNA methylome of myelofibrosis patients using high-density DNA methylation arrays. We detected 35,215 differentially methylated CpG, corresponding to 10,253 genes, between myelofibrosis patients and healthy controls. These changes were present both in primary and se...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Martínez-Calle, Nicolás, Pascual, Marien, Ordoñez, Raquel, Enériz, Edurne San José, Kulis, Marta, Miranda, Estíbaliz, Guruceaga, Elisabeth, Segura, Víctor, Larráyoz, María José, Bellosillo, Beatriz, Calasanz, María José, Besses, Carles, Rifón, José, Martín-Subero, José I., Agirre, Xabier, Prosper, Felipe
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669145/
https://ncbi.nlm.nih.gov/pubmed/30655376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.204917
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