Structural basis and mechanism for metallochaperone-assisted assembly of the Cu(A) center in cytochrome oxidase

The mechanisms underlying the biogenesis of the structurally unique, binuclear Cu(1.5+)•Cu(1.5+) redox center (Cu(A)) on subunit II (CoxB) of cytochrome oxidases have been a long-standing mystery. Here, we reconstituted the CoxB•Cu(A) center in vitro from apo-CoxB and the holo-forms of the copper tr...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Canonica, Fabia, Klose, Daniel, Ledermann, Raphael, Sauer, Maximilian M., Abicht, Helge K., Quade, Nick, Gossert, Alvar D., Chesnov, Serge, Fischer, Hans-Martin, Jeschke, Gunnar, Hennecke, Hauke, Glockshuber, Rudi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2019
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669012/
https://ncbi.nlm.nih.gov/pubmed/31392273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw8478
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