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Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7
Apoptosis is a complex multi-step process driven by caspase-dependent proteolytic cleavage cascades. Dysregulation of apoptosis promotes tumorigenesis and limits the efficacy of chemotherapy. To assess the complex interactions among caspases during apoptosis, we disrupted caspase-8, -9, -3, -7, or -...
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| Pubblicato in: | Sci Adv |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Association for the Advancement of Science
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6669006/ https://ncbi.nlm.nih.gov/pubmed/31392262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau9433 |
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