Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7

Apoptosis is a complex multi-step process driven by caspase-dependent proteolytic cleavage cascades. Dysregulation of apoptosis promotes tumorigenesis and limits the efficacy of chemotherapy. To assess the complex interactions among caspases during apoptosis, we disrupted caspase-8, -9, -3, -7, or -...

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Bibliografische gegevens
Gepubliceerd in:Sci Adv
Hoofdauteurs: McComb, Scott, Chan, Pik Ki, Guinot, Anna, Hartmannsdottir, Holmfridur, Jenni, Silvia, Dobay, Maria Pamela, Bourquin, Jean-Pierre, Bornhauser, Beat C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Association for the Advancement of Science 2019
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669006/
https://ncbi.nlm.nih.gov/pubmed/31392262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau9433
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