Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukaemia cells

OBJECTIVES: Epigenetic modifiers were important players in the development of haematological malignancies and sensitivity to therapy. Mutations of SET domain‐containing 2 (SETD2), a methyltransferase that catalyses the trimethylation of histone 3 on lysine 36 (H3K36me3), were found in various myeloi...

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Vydáno v:Cell Prolif
Hlavní autoři: Sheng, Yaru, Ji, Zhongzhong, Zhao, Huifang, Wang, Jinming, Cheng, Chaping, Xu, Weimin, Wang, Xue, He, Yuman, Liu, Kaiyuan, Li, Li, Voeltzel, Thibault, Maguer‐Satta, Veronique, Gao, Wei‐Qiang, Zhu, Helen He
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668982/
https://ncbi.nlm.nih.gov/pubmed/31054182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12611
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