Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature

Oxidative stress plays an important role in aging-related neurodegeneration. This study used littermates of WT and Nox2-knockout (Nox2KO) mice plus endothelial cell–specific human Nox2 overexpression–transgenic (HuNox2Tg) mice to investigate Nox2-derived ROS in brain aging. Compared with young WT mi...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Fan, Lampson M., Geng, Li, Cahill-Smith, Sarah, Liu, Fangfei, Douglas, Gillian, Mckenzie, Chris-Anne, Smith, Colin, Brooks, Gavin, Channon, Keith M., Li, Jian-Mei
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668817/
https://ncbi.nlm.nih.gov/pubmed/31329158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125173
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