The local immune landscape determines tumor PD-L1 heterogeneity and sensitivity to therapy

Programmed death-1 receptor ligand 1 (PD-L1) is a promising therapeutic target in aggressive cancers. However, immune landscapes and cancer hallmarks of human PD-L1(+) tumors as well as their roles in determining therapeutic efficacies are unknown. Here, we showed, in detailed studies of gene data r...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wei, Yuan, Zhao, Qiyi, Gao, Zhiliang, Lao, Xiang-Ming, Lin, Wei-Ming, Chen, Dong-Ping, Mu, Ming, Huang, Chun-Xiang, Liu, Zheng-Yu, Li, Bo, Zheng, Limin, Kuang, Dong-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668685/
https://ncbi.nlm.nih.gov/pubmed/31112529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127726
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