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Targeted Promoter Replacement Reveals That Herpes Simplex Virus Type-1 and 2 Specific VP16 Promoters Direct Distinct Rates of Entry Into the Lytic Program in Sensory Neurons in vivo

Infection and life-long residence in the human nervous system is central to herpes simplex virus (HSV) pathogenesis. Access is gained through innervating axonal projections of sensory neurons. This distinct mode of entry separates the viral genome from tegument proteins, including the potent transac...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Thompson, Richard L., Sawtell, Nancy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668326/
https://ncbi.nlm.nih.gov/pubmed/31396171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.01624
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