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Naturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability
BACKGROUND: Mutations in the PB1 subunit of RNA-dependent RNA polymerase (RdRp) of influenza A virus can affect replication fidelity. Before the influenza A/H1N1 pandemic in 2009, most human influenza A/H1N1 viruses contained the avian-associated residue, serine, at position 216 in PB1. However, nea...
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| Veröffentlicht in: | J Biomed Sci |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6668090/ https://ncbi.nlm.nih.gov/pubmed/31366399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-019-0547-4 |
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