Recruitment of Intratumoral CD103(+) Dendritic Cells by a CXCR4 Antagonist-Armed Virotherapy Enhances Antitumor Immunity

Intratumoral dendritic cells play an important role in stimulating cytotoxic T cells and driving antitumor immunity. Using a metastatic ovarian tumor model in syngeneic mice, we explored whether therapy with a CXCR4 antagonist-armed oncolytic vaccinia virus activates endogenous CD103(+) dendritic ce...

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Publicat a:Mol Ther Oncolytics
Autors principals: Mistarz, Anna, Komorowski, Marcin P., Graczyk, Matthew A., Gil, Margaret, Jiang, Aimin, Opyrchal, Mateusz, Rokita, Hanna, Odunsi, Kunle O., Kozbor, Danuta
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667789/
https://ncbi.nlm.nih.gov/pubmed/31384667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2019.06.003
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