Clostridium perfringens epsilon toxin vaccine candidate lacking toxicity to cells expressing myelin and lymphocyte protein

A variant form of Clostridium perfringens epsilon toxin (Y30A-Y196A) with mutations, which shows reduced binding to Madin–Darby canine kidney (MDCK) cells and reduced toxicity in mice, has been proposed as the next-generation enterotoxaemia vaccine. Here we show that, unexpectedly, the Y30A-Y196A va...

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Bibliografiske detaljer
Udgivet i:NPJ Vaccines
Main Authors: Morcrette, Helen, Bokori-Brown, Monika, Ong, Stephanie, Bennett, Leo, Wren, Brendan W., Lewis, Nick, Titball, Richard W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667452/
https://ncbi.nlm.nih.gov/pubmed/31372245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-019-0128-2
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