Discovery and preclinical characterization of [(18)F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

PURPOSE: Tau deposition is a key pathological feature of Alzheimer’s disease (AD) and other neurodegenerative disorders. The spreading of tau neurofibrillary tangles across defined brain regions corresponds to the observed level of cognitive decline in AD. Positron-emission tomography (PET) has prov...

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Dettagli Bibliografici
Pubblicato in:Eur J Nucl Med Mol Imaging
Autori principali: Kroth, Heiko, Oden, Felix, Molette, Jerome, Schieferstein, Hanno, Capotosti, Francesca, Mueller, Andre, Berndt, Mathias, Schmitt-Willich, Heribert, Darmency, Vincent, Gabellieri, Emanuele, Boudou, Cédric, Juergens, Tanja, Varisco, Yvan, Vokali, Efthymia, Hickman, David T., Tamagnan, Gilles, Pfeifer, Andrea, Dinkelborg, Ludger, Muhs, Andreas, Stephens, Andrew
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2019
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667408/
https://ncbi.nlm.nih.gov/pubmed/31264169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-019-04397-2
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