Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA

NogoA inhibits neurite outgrowth of motoneurons (NOM) through interaction with its receptors, Nogo66/NgR. Inhibition of Nogo receptors rescues NOM, but not to the extent exhibited by NogoA-knockout mice, suggesting the presence of other pathways. We found that NogoA-overexpressing muscle cells reduc...

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Udgivet i:eLife
Main Authors: Lin, Cheng Yung, Wu, Chia Lun, Lee, Kok Zhi, Chen, You Jei, Zhang, Po Hsiang, Chang, Chia Yu, Harn, Horng Jyh, Lin, Shinn Zong, Tsai, Huai Jen
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667276/
https://ncbi.nlm.nih.gov/pubmed/31361595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49175
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