Kinase-Dead Knock-In Mouse Reveals an Essential Role of Kinase Activity of Ca(2+)/Calmodulin-Dependent Protein Kinase IIα in Dendritic Spine Enlargement, Long-Term Potentiation, and Learning

Ca(2+)/calmodulin-dependent protein kinase IIα (CaMKIIα) is an essential mediator of activity-dependent synaptic plasticity that possesses multiple protein functions. So far, the autophosphorylation site-mutant mice targeted at T286 and at T305/306 have demonstrated the importance of the autonomous...

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Publicat a:J Neurosci
Autors principals: Yamagata, Yoko, Kobayashi, Shizuka, Umeda, Tatsuya, Inoue, Akihiro, Sakagami, Hiroyuki, Fukaya, Masahiro, Watanabe, Masahiko, Hatanaka, Nobuhiko, Totsuka, Masako, Yagi, Takeshi, Obata, Kunihiko, Imoto, Keiji, Yanagawa, Yuchio, Manabe, Toshiya, Okabe, Shigeo
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665418/
https://ncbi.nlm.nih.gov/pubmed/19515929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0707-09.2009
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