Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS), characterized by degeneration of spinal motor neurons, consists of sporadic and familial forms. One cause of familial ALS is missense mutations in the superoxide dismutase 1 (SOD1) gene. Iron accumulation occurs in the CNS of both forms of ALS; however, its contr...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Jeong, Suh Young, Rathore, Khizr I., Schulz, Katrin, Ponka, Prem, Arosio, Paolo, David, Samuel
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665152/
https://ncbi.nlm.nih.gov/pubmed/19158288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5443-08.2009
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