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Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS), characterized by degeneration of spinal motor neurons, consists of sporadic and familial forms. One cause of familial ALS is missense mutations in the superoxide dismutase 1 (SOD1) gene. Iron accumulation occurs in the CNS of both forms of ALS; however, its contr...

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Bibliografski detalji
Izdano u:J Neurosci
Glavni autori: Jeong, Suh Young, Rathore, Khizr I., Schulz, Katrin, Ponka, Prem, Arosio, Paolo, David, Samuel
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665152/
https://ncbi.nlm.nih.gov/pubmed/19158288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5443-08.2009
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