H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification

Gene silencing by chromatin compaction is integral to establishing and maintaining cell fates. Trimethylated histone 3 lysine 9 (H3K9me3)-marked heterochromatin is reduced in embryonic stem cells compared to differentiated cells. However, the establishment and dynamics of closed regions of chromatin...

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Vydáno v:Science
Hlavní autoři: Nicetto, Dario, Donahue, Greg, Jain, Tanya, Peng, Tao, Sidoli, Simone, Sheng, Lihong, Montavon, Thomas, Becker, Justin S., Grindheim, Jessica M., Blahnik, Kimberly, Garcia, Benjamin A., Tan, Kai, Bonasio, Roberto, Jenuwein, Thomas, Zaret, Kenneth S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664818/
https://ncbi.nlm.nih.gov/pubmed/30606806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau0583
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