Single and dual targeting of mutant EGFR with an allosteric inhibitor

Allosteric kinase inhibitors offer a potentially complementary therapeutic strategy to ATP-competitive kinase inhibitors due to their distinct sites of target binding. In the present study, we identify and study a mutant-selective EGFR allosteric inhibitor, JBJ-04-125-02, which as a single agent, ca...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Discov
Auteurs principaux: To, Ciric, Jang, Jaebong, Chen, Ting, Park, Eunyoung, Mushajiang, Mierzhati, De Clercq, Dries J. H., Xu, Man, Wang, Stephen, Cameron, Michael D., Heppner, David E., Shin, Bo Hee, Gero, Thomas W., Yang, Annan, Dahlberg, Suzanne E., Wong, Kwok-Kin, Eck, Michael J., Gray, Nathanael S., Jänne, Pasi A.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664433/
https://ncbi.nlm.nih.gov/pubmed/31092401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0903
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