Method Validation for Simultaneous Quantification of Olmesartan and Hydrochlorothiazide in Human Plasma Using LC-MS/MS and Its Application Through Bioequivalence Study in Healthy Volunteers

A new, simple, sensitive, selective, rapid, and high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for simultaneous quantification of Olmesartan and hydrochlorothiazide in human plasma. Simple liquid–liquid extraction procedure was appli...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Kumar, Arvind, Dwivedi, Surya Prakash, Prasad, Tulika
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664239/
https://ncbi.nlm.nih.gov/pubmed/31396085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00810
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