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Target sequence requirements of a type III-B CRISPR-Cas immune system

CRISPR-Cas systems are RNA-based immune systems that protect many prokaryotes from invasion by viruses and plasmids. Type III CRISPR systems are unique, as their targeting mechanism requires target transcription. Upon transcript binding, DNA cleavage by type III effector complexes is activated. Type...

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Vydáno v:J Biol Chem
Hlavní autoři: Johnson, Kaitlin, Learn, Brian A., Estrella, Michael A., Bailey, Scott
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664175/
https://ncbi.nlm.nih.gov/pubmed/31110048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008728
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