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Uptake and efflux of FL118 and two FL118 derivatives in 3D cell model

Drug uptake and efflux are two of the critical factors required in order to be able to define drug efficacy. This study aims to investigate cytotoxicity and uptake mechanisms of two FL118 analogues (7-Q20 and val-FL118) in parallel with FL118 in three-dimensional multi-cellular spheroids model. The...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cytotechnology
Hauptverfasser: Zhou, Leilei, Weng, Qi, Zheng, Yixin, Zhou, Yuqin, Li, Qingyong, Li, Fengzhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Netherlands 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663949/
https://ncbi.nlm.nih.gov/pubmed/31309350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-019-00322-5
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