Virion-associated, host-derived DHX9/RNA helicase A enhances the processivity of HIV-1 reverse transcriptase on genomic RNA

DHX9/RNA helicase A (RHA) is a host RNA helicase that participates in many critical steps of the HIV-1 life cycle. It co-assembles with the viral RNA genome into the capsid core. Virions deficient in RHA are less infectious as a result of reduced reverse transcription efficiency, demonstrating that...

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Udgivet i:J Biol Chem
Main Authors: Brady, Samantha, Singh, Gatikrushna, Bolinger, Cheryl, Song, Zhenwei, Boeras, Ioana, Weng, Kexin, Trent, Bria, Brown, William Clay, Singh, Kamalendra, Boris-Lawrie, Kathleen, Heng, Xiao
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663884/
https://ncbi.nlm.nih.gov/pubmed/31175158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007679
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