E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2

The E3 ubiquitin-protein ligase TRIM21, of the RING-containing tripartite motif (TRIM) protein family, is a major autoantigen in autoimmune diseases and a modulator of innate immune signaling. Together with ubiquitin-conjugating enzyme E2 E1 (UBE2E1), TRIM21 acts both as an E3 ligase and as a substr...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Anandapadamanaban, Madhanagopal, Kyriakidis, Nikolaos C., Csizmók, Veronika, Wallenhammar, Amélie, Espinosa, Alexander C., Ahlner, Alexandra, Round, Adam R., Trewhella, Jill, Moche, Martin, Wahren-Herlenius, Marie, Sunnerhagen, Maria
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663867/
https://ncbi.nlm.nih.gov/pubmed/31160341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008485
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