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Catalytically Competent Non-transforming H-RAS(G12P) Mutant Provides Insight into Molecular Switch Function and GAP-independent GTPase Activity of RAS
RAS mutants have been extensively studied as they are associated with development of cancer; however, H-RAS(G12P) mutant has remained untouched since it does not lead to transformation in the cell. To the best of our knowledge, this is the first study where structural/dynamical properties of H-RAS(G...
Guardat en:
| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6662853/ https://ncbi.nlm.nih.gov/pubmed/31358828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47481-1 |
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