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Short amylin receptor antagonist peptides improve memory deficits in Alzheimer’s disease mouse model

Recent evidence supports involvement of amylin and the amylin receptor in the pathogenesis of Alzheimer’s disease (AD). We have previously shown that amylin receptor antagonist, AC253, improves spatial memory in AD mouse models. Herein, we generated and screened a peptide library and identified two...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Soudy, Rania, Kimura, Ryoichi, Patel, Aarti, Fu, Wen, Kaur, Kamaljit, Westaway, David, Yang, Jing, Jhamandas, Jack
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662706/
https://ncbi.nlm.nih.gov/pubmed/31358858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47255-9
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