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Short amylin receptor antagonist peptides improve memory deficits in Alzheimer’s disease mouse model

Recent evidence supports involvement of amylin and the amylin receptor in the pathogenesis of Alzheimer’s disease (AD). We have previously shown that amylin receptor antagonist, AC253, improves spatial memory in AD mouse models. Herein, we generated and screened a peptide library and identified two...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Soudy, Rania, Kimura, Ryoichi, Patel, Aarti, Fu, Wen, Kaur, Kamaljit, Westaway, David, Yang, Jing, Jhamandas, Jack
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662706/
https://ncbi.nlm.nih.gov/pubmed/31358858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47255-9
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