Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival

The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory properties of cancer cells. To address this question, w...

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Pubblicato in:Sci Rep
Autori principali: Nair, Nishanth Ulhas, Das, Avinash, Rogkoti, Vasiliki-Maria, Fokkelman, Michiel, Marcotte, Richard, de Jong, Chiaro G., Koedoot, Esmee, Lee, Joo Sang, Meilijson, Isaac, Hannenhalli, Sridhar, Neel, Benjamin G., de Water, Bob van, Le Dévédec, Sylvia E., Ruppin, Eytan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662662/
https://ncbi.nlm.nih.gov/pubmed/31358840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47440-w
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