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Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures

Exposure to stressors primes neuroinflammatory responses to subsequent immune challenges and stress-induced glucocorticoids (GCs) play a mediating role in this phenomenon of neuroinflammatory priming. Recent evidence also suggests that the alarmin high-mobility group box-1 (HMGB1) and the microglial...

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Detalhes bibliográficos
Publicado no:Brain Behav Immun
Main Authors: Frank, Matthew G., Annis, Jessica L., Watkins, Linda R., Maier, Steven F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662571/
https://ncbi.nlm.nih.gov/pubmed/31078691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2019.05.014
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