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The three-dimensional organization of the genome in cellular senescence and age-associated diseases.

Recent advances in genomics and imaging technologies have increased our ability to interrogate the 3D conformation of chromosomes and to better understand principles of organization and dynamics, as well as how their alteration can lead to disease. In this review we describe how these technologies h...

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Veröffentlicht in:Semin Cell Dev Biol
Hauptverfasser: Evans, Shane, Horrell, Jeremy, Neretti, Nicola
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6661233/
https://ncbi.nlm.nih.gov/pubmed/30031215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2018.07.022
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