Novel Poly(Adenosine Diphosphate-Ribose) Polymerase (PARP) Inhibitor, AZD2461, Down-Regulates VEGF and Induces Apoptosis in Prostate Cancer Cells

BACKGROUND: Prostate cancer (Pca) is a heterogeneous disease, and current treatments are not based on molecular stratification. Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors have recently been found to be remarkably toxic to cells with defects in homologous recombination, par...

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Publicado en:Iran Biomed J
Autores principales: Sargazi, Saman, Saravani, Ramin, Zavar Reza, Javad, Zarei Jaliani, Hossein, Galavi, Hamidreza, Moudi, Mahdiyeh, Alsadat Abtahi, Najmeh
Formato: Artigo
Lenguaje:Inglês
Publicado: Pasteur Institute of Iran 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6661129/
https://ncbi.nlm.nih.gov/pubmed/31102368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.29252/.23.5.312
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