Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin

Acidic pH in the tumor microenvironment is associated with cancer metabolism and creates a physiological barrier that prevents from drugs to penetrate cells. Specifically, ionizable weak-base drugs, such as doxorubicin, freely permeate membranes in their uncharged form, however, in the acidic tumor...

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Veröffentlicht in:J Control Release
Hauptverfasser: Abumanhal-Masarweh, Hanan, Koren, Lilach, Zinger, Assaf, Yaari, Zvi, Krinsky, Nitzan, Kaneti, Galoz, Dahan, Nitsan, Lupu-Haber, Yael, Suss-Toby, Edith, Weiss-Messer, Esther, Schlesinger-Laufer, Michal, Shainsky-Roitman, Janna, Schroeder, Avi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660974/
https://ncbi.nlm.nih.gov/pubmed/30615983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.01.004
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