Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin

Acidic pH in the tumor microenvironment is associated with cancer metabolism and creates a physiological barrier that prevents from drugs to penetrate cells. Specifically, ionizable weak-base drugs, such as doxorubicin, freely permeate membranes in their uncharged form, however, in the acidic tumor...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:J Control Release
Hoofdauteurs: Abumanhal-Masarweh, Hanan, Koren, Lilach, Zinger, Assaf, Yaari, Zvi, Krinsky, Nitzan, Kaneti, Galoz, Dahan, Nitsan, Lupu-Haber, Yael, Suss-Toby, Edith, Weiss-Messer, Esther, Schlesinger-Laufer, Michal, Shainsky-Roitman, Janna, Schroeder, Avi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660974/
https://ncbi.nlm.nih.gov/pubmed/30615983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.01.004
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items