Φορτώνει......
Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin
Acidic pH in the tumor microenvironment is associated with cancer metabolism and creates a physiological barrier that prevents from drugs to penetrate cells. Specifically, ionizable weak-base drugs, such as doxorubicin, freely permeate membranes in their uncharged form, however, in the acidic tumor...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Control Release |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6660974/ https://ncbi.nlm.nih.gov/pubmed/30615983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.01.004 |
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