Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer

BACKGROUND: Synthetic lethal interactions (SLIs) that occur between gene pairs are exploited for cancer therapeutics. Studies in the model eukaryote yeast have identified ~ 550,000 negative genetic interactions that have been extensively studied, leading to characterization of novel pathways and gen...

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Publicat a:BMC Med Genomics
Autors principals: Kirzinger, Morgan W. B., Vizeacoumar, Frederick S., Haave, Bjorn, Gonzalez-Lopez, Cristina, Bonham, Keith, Kusalik, Anthony, Vizeacoumar, Franco J.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660958/
https://ncbi.nlm.nih.gov/pubmed/31351478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-019-0554-z
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