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Gene function prediction from congruent synthetic lethal interactions in yeast

We predicted gene function using synthetic lethal genetic interactions between null alleles in Saccharomyces cerevisiae. Phenotypic and protein interaction data indicate that synthetic lethal gene pairs function in parallel or compensating pathways. Congruent gene pairs, defined as sharing synthetic...

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Bibliografische gegevens
Hoofdauteurs: Ye, Ping, Peyser, Brian D, Pan, Xuewen, Boeke, Jef D, Spencer, Forrest A, Bader, Joel S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2005
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1681444/
https://ncbi.nlm.nih.gov/pubmed/16729061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb4100034
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