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Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing
Transcription of transposable elements is tightly regulated to prevent genome damage. KRAB domain-containing zinc finger proteins (KRAB-ZFPs) and KRAB-associated protein 1 (KAP1/TRIM28) play a key role in regulating retrotransposons. KRAB-ZFPs recognize specific retrotransposon sequences and recruit...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6660772/ https://ncbi.nlm.nih.gov/pubmed/31289231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901318116 |
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