pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis

Axonal degeneration is central to clinical disability and disease progression in multiple sclerosis (MS). Myeloid cells such as brain-resident microglia and blood-borne monocytes are thought to be critically involved in this degenerative process. However, the exact underlying mechanisms have still n...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kremer, David, Gruchot, Joel, Weyers, Vivien, Oldemeier, Lisa, Göttle, Peter, Healy, Luke, Ho Jang, Jeong, Kang T. Xu, Yu, Volsko, Christina, Dutta, Ranjan, Trapp, Bruce D., Perron, Hervé, Hartung, Hans-Peter, Küry, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660731/
https://ncbi.nlm.nih.gov/pubmed/31213545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901283116
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