Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

Neuropilin-1 (Nrp-1) is a marker for murine CD4(+)FoxP3(+) regulatory T (Treg) cells, a subset of human CD4(+) Treg cells, and a population of CD8(+) T cells infiltrating certain solid tumours. However, whether Nrp-1 regulates tumour-specific CD8 T-cell responses is still unclear. Here we show that...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Leclerc, Marine, Voilin, Elodie, Gros, Gwendoline, Corgnac, Stéphanie, de Montpréville, Vincent, Validire, Pierre, Bismuth, Georges, Mami-Chouaib, Fathia
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659631/
https://ncbi.nlm.nih.gov/pubmed/31350404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11280-z
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