Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma

Targeting the B-cell receptor and phosphatidylinositol 3-kinase/mTOR signaling pathways has shown meaningful, but incomplete, antitumor activity in lymphoma. Glycogen synthase kinase 3 (GSK3) α and β are 2 homologous and functionally overlapping serine/threonine kinases that phosphorylate multiple p...

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Publicado en:Blood
Autores principales: Wu, Xiaosheng, Stenson, Mary, Abeykoon, Jithma, Nowakowski, Kevin, Zhang, Lianwen, Lawson, Joshua, Wellik, Linda, Li, Ying, Krull, Jordan, Wenzl, Kerstin, Novak, Anne J., Ansell, Stephen M., Bishop, Gail A., Billadeau, Daniel D., Peng, Kah Whye, Giles, Francis, Schmitt, Daniel M., Witzig, Thomas E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2019
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659256/
https://ncbi.nlm.nih.gov/pubmed/31101621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018874560
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