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The Warburg effect: persistence of stem-cell metabolism in cancers as a failure of differentiation

BACKGROUND: Two recent observations regarding the Warburg effect are that (i) the metabolism of stem cells is constitutive (aerobic) glycolysis while normal cellular differentiation involves a transition to oxidative phosphorylation and (ii) the degree of glucose uptake of a malignancy as imaged by...

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Detalles Bibliográficos
Publicado en:Ann Oncol
Main Authors: Riester, M, Xu, Q, Moreira, A, Zheng, J, Michor, F, Downey, R J
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658717/
https://ncbi.nlm.nih.gov/pubmed/29045536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdx645
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