Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection

Therapeutic vaccination against chronic hepatitis B must overcome high viral antigen load and local regulatory mechanisms that promote immune-tolerance in the liver and curtail hepatitis B virus (HBV)-specific CD8 T cell immunity. Here, we report that therapeutic heterologous HBcore-protein-prime/Mo...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Kosinska, Anna D., Moeed, Abdul, Kallin, Nina, Festag, Julia, Su, Jinpeng, Steiger, Katja, Michel, Marie-Louise, Protzer, Ulrike, Knolle, Percy A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658704/
https://ncbi.nlm.nih.gov/pubmed/31346211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47149-w
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